Joyce became CEO of Qantas on 28 November 2008. He is a former Director of Orangestar Investment Holdings Pte Limited (holding company of Singapore-based Jetstar Asia Airways and Valuair) and Jetstar Pacific Airlines Aviation Joint Stock Company (in Vietnam). On 29 October 2011, as a result of continuing industrial unrest following the announcement of job losses and structural changes at Qantas, Joyce grounded the entire Qantas mainline fleet.
The airline is based in the Sydney suburb of Mascot with its main hub at Sydney Airport. Qantas has a 65% share of the Australian domestic market and carries 18.7% of all passengers travelling in and out of Australia.